Insights into GPCR Drug Discovery & Development
Explore GPCR-Ligand Interactions & Signaling Pathways with Binding & Functional Assays G protein-coupled receptors (GPCRs) represent the largest family of validated therapeutic... Read More
Do-It-Yourself: Benefits and Challenges of Creating Your Own Cell-Based Assays
Do-It-Yourself Cell-Based Assays Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or... Read More
Critical Needs in Cellular Target Engagement
Cellular Target Engagement Challenges and Needs The development of new medicines for treating diseases and new chemical probes for elucidating biological function... Read More
Ideal Methods to Study Cellular Transport of Membrane Proteins
Translocation and Trafficking of Membrane Proteins Membrane proteins (such as receptors like GPCRs and ion channels) are translated and undergo proper folding... Read More
Why Study GPCR Arrestin Recruitment?
GPCR β-Arrestin Signaling Arrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation... Read More