GPCR Drug Discovery & Development Insights with Dr. Terry Kenakin
Q: WHAT IS THE IMPORTANCE OF GPCRs IN DRUG DISCOVERY AND DEVELOPMENT? A: GPCRs have long been regarded as a low-hanging fruit... Read More
Employing Assay “Volume Control” to Unveil Efficacies in Allosteric Lead Molecules for GPCRs
Drugs interact with living physiology; an in vitro assay of drug activity can be considered a snapshot of the full movie seen... Read More
Four Reasons Why You Should Measure and Quantify Signaling Bias in Your Molecules
Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure agonist-induced activation... Read More