Accelerating Development of GLP-1 & GLP-2 Therapeutics with Validated Bioassays
Glucagon-like peptides, GLP-1 & GLP-2, are well-researched, metabolically significant peptide hormones secreted from the L-cells of the small intestine in response to... Read More
GPCR Drug Discovery & Development Insights with Dr. Terry Kenakin
Q: WHAT IS THE IMPORTANCE OF GPCRs IN DRUG DISCOVERY AND DEVELOPMENT? A: GPCRs have long been regarded as a low-hanging fruit... Read More
Employing Assay “Volume Control” to Unveil Efficacies in Allosteric Lead Molecules for GPCRs
Drugs interact with living physiology; an in vitro assay of drug activity can be considered a snapshot of the full movie seen... Read More
Evaluate GLP-1R Targeted Therapeutics Using First-to-Market Semaglutide Qualified GLP-1R Bioassay
Glucagon-Like Peptide-1 (GLP-1), a member of the glucagon-secretin peptide family, is secreted from L-cells of the small intestine and binds to GLP-1... Read More
SPRINTer Platform: Detection of Endogenous Protein Turnover by Targeted Degraders
A novel and growing modality in drug discovery has been the application of Targeted Protein Degradation (TPD). TPD involves the use of... Read More
Insights into GPCR Drug Discovery & Development
Explore GPCR-Ligand Interactions & Signaling Pathways with Binding & Functional Assays G protein-coupled receptors (GPCRs) represent the largest family of validated therapeutic... Read More
Accelerating Biologics Therapeutics with Bioassays: An In-Depth Discussion on the Essence of Bioassays Implemented for Drug Development
Eurofins DiscoverX, in conjunction with Drug Target Review, sponsored and moderated a Bioassay roundtable discussion webinar with group leaders from industry’s leading... Read More
ACCELERATING CYTOKINE DRUG DISCOVERY AND QC LOT RELEASE TESTING WITH QUALIFIED, FUNCTIONAL CELL-BASED ASSAYS
Cytokines and their receptors have emerged as major drug targets for inflammatory and autoimmune diseases, allergies, and, more recently, in cancer immunotherapies... Read More
EMPLOYING KILR CYTOTOXICITY READY-TO-USE BIOASSAYS FROM SCREENING TO LOT-RELEASE APPLICATIONS
Webinar Highlights and Q&A Webinar: Cytotoxicity Bioassays – Measuring Antibody-Mediated Direct Cell Death (watch webinar) Therapeutic antibodies that can elicit different applications... Read More
Unlocking Orphan GPCRs with an Innovative Forward Trafficking Approach
Application of GPCR Pharmacotrafficking & Cell-Based Assays Orphan G Protein-Coupled Receptors (oGPCRs) comprise one-third of the druggable GPCR space1. Despite their pharmacotherapeutic... Read More