Webinar Recap: Unlocking GPCR’s for Oncology
Surprisingly few GPCR-targeted therapies have been developed for oncology, despite frequent disregulation of the receptors and their signaling mediators that control pro-survival... Read More
Four Reasons Why You Should Measure and Quantify Signaling Bias in Your Molecules
Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure agonist-induced activation... Read More
Chemical Probes Portal – Know Your Selectivity!
The Chemical Probes Portal is a new online resource for anyone using tool compounds in their research. We can learn a lot... Read More
Why Study GPCR Arrestin Recruitment?
GPCR β-Arrestin Signaling Arrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation... Read More
Ligand Bias: Increasing Specificity and Reducing Side Effects of Drug Compounds
Ligand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is a relatively... Read More
DiscoverX European GPCR Symposium 2016
Engage in discussion about natural biased ligands on April 12, 2016 in Cambridge, UK at the European DiscoverX GPCR Symposium. This is... Read More