Four Reasons Why You Should Measure and Quantify Signaling Bias in Your Molecules
Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure agonist-induced activation... Read More
Kinome-wide Profiling of Existing Chemical Assets: A Powerful Strategy to Jump-start New Drug Discovery Programs
Kinase inhibitors are among the fastest growing classes of FDA-approved drugs, and it has been satisfying to see that three have now... Read More