Chemical Probes Portal – Know Your Selectivity!
The Chemical Probes Portal is a new online resource for anyone using tool compounds in their research. We can learn a lot... Read More
Why Study GPCR Arrestin Recruitment?
GPCR β-Arrestin Signaling Arrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation... Read More
Ligand Bias: Increasing Specificity and Reducing Side Effects of Drug Compounds
Ligand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is a relatively... Read More
3 Key Trends in Drug Discovery Outsourcing for 2016
In 2011 the pharmaceutical industry was presented with a major challenge. The peak of the patent cliff was approaching with over $30... Read More
Developing a Simple Antibody Dependent Cell-mediated Cytotoxicity Assay to Measure Target Cell Death
Most therapeutic antibodies have a Fab’ region that binds the antigen, and an Fc region which binds to and activates various cell... Read More
DiscoverX European GPCR Symposium 2016
Engage in discussion about natural biased ligands on April 12, 2016 in Cambridge, UK at the European DiscoverX GPCR Symposium. This is... Read More
Cell-based Assays for Immunotherapy Drug Development
Review this new presentation on SlideShare to learn about novel cell-based assays that enable improved immunotherapy drug development. See case studies utilizing... Read More