Do-It-Yourself: Benefits and Challenges of Creating Your Own Cell-Based Assays
Do-It-Yourself Cell-Based Assays Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or... Read More
Driving Robust ADCC and T Cell Redirection with KILR® CD16 Effector Cells
Class I therapeutic antibodies achieve their clinical efficacy not only by binding to their target antigen but also through Fc domain-mediated recruitment... Read More
Webinar Recap: Unlocking GPCR’s for Oncology
Surprisingly few GPCR-targeted therapies have been developed for oncology, despite frequent disregulation of the receptors and their signaling mediators that control pro-survival... Read More
Critical Needs in Cellular Target Engagement
Cellular Target Engagement Challenges and Needs The development of new medicines for treating diseases and new chemical probes for elucidating biological function... Read More
Ideal Methods to Study Cellular Transport of Membrane Proteins
Translocation and Trafficking of Membrane Proteins Membrane proteins (such as receptors like GPCRs and ion channels) are translated and undergo proper folding... Read More
Chemical Probes Portal – Know Your Selectivity!
The Chemical Probes Portal is a new online resource for anyone using tool compounds in their research. We can learn a lot... Read More
Why Study GPCR Arrestin Recruitment?
GPCR β-Arrestin Signaling Arrestins are ubiquitously expressed and function in the activation of GPCRs, desensitization of most 7-transmembrane receptors (7-TMs), and regulation... Read More
Phenotypic Profiling is on the Rise!
Three terrific review articles that explain why pharma is moving from target to phenotype For some years now, there has been a... Read More
Ligand Bias: Increasing Specificity and Reducing Side Effects of Drug Compounds
Ligand bias is the ability of compounds to exert differential signal transduction responses on activation of a GPCR. This is a relatively... Read More
3 Key Trends in Drug Discovery Outsourcing for 2016
In 2011 the pharmaceutical industry was presented with a major challenge. The peak of the patent cliff was approaching with over $30... Read More