Do-It-Yourself: Benefits and Challenges of Creating Your Own Cell-Based Assays
Do-It-Yourself Cell-Based Assays Cell-based assays are useful for understanding cellular pathways; characterizing targets and their function; identifying, screening, and optimizing ligands or... Read More
An Expanding Chemogenomic Toolbox Gives Kinome Research a Welcome and Much Needed Boost
The human kinome includes 500+ druggable targets, with 35+ small molecule kinase inhibitors approved by the FDA since 2000. Remarkable. Despite the... Read More
The Mast Cell Receptor MRGX2 and Drug-Induced Anaphylaxis
In a recent webinar Dr. Andrew J Brown, Research Fellow, GSK, presented a compelling narrative on the pharmacological characterization of the MRGX2... Read More
Driving Robust ADCC and T Cell Redirection with KILR® CD16 Effector Cells
Class I therapeutic antibodies achieve their clinical efficacy not only by binding to their target antigen but also through Fc domain-mediated recruitment... Read More
Biological Validation of the BioMAP® Platform with Phenotypic Chemical Probes
Phenotypic chemical biology is the use of target-selective chemical probes and drugs in cell-based or in vivo assays for establishing target function... Read More
Webinar Recap: Unlocking GPCR’s for Oncology
Surprisingly few GPCR-targeted therapies have been developed for oncology, despite frequent disregulation of the receptors and their signaling mediators that control pro-survival... Read More
Critical Needs in Cellular Target Engagement
Cellular Target Engagement Challenges and Needs The development of new medicines for treating diseases and new chemical probes for elucidating biological function... Read More
Four Reasons Why You Should Measure and Quantify Signaling Bias in Your Molecules
Most GPCRs are pleiotropically coupled to multiple signaling pathways in cells and the availability of functional assays to separately measure agonist-induced activation... Read More
Discovering a New Class of Anti-Cancer Compounds
Oncoceutics, Inc. is a clinical-stage biotech company developing a novel class of small molecule compounds for oncology called imipridones that selectively target... Read More
Ideal Methods to Study Cellular Transport of Membrane Proteins
Translocation and Trafficking of Membrane Proteins Membrane proteins (such as receptors like GPCRs and ion channels) are translated and undergo proper folding... Read More